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EMA Leaks: Truncated Transcripts
It is finally here; the in-depth discussion on the EMA leaks
Most of the public trusted experts (the ones on our side of the fence) have let the public down.
With rare exceptions of the BMJ, Jessica Rose and after much wrangling, Steve Kirsch, even after two years and a landslide of evidence showing SARS-CoV-2 shot harms, no-one wants to report on the EMA leak documents. A de facto victory for pharmaceutical intimidation and censorship.
My hope was a copy of the documents I received could be referred to experts, not only for validation (what the BMJ did), but also for much deeper analysis and a discussion of ramifications.
They have chickened out, betrayed a public to death for safety, abandoning their ramparts. Only my hamfisted interpretations are available.
I have not abandoned my post.
Loss Of Poly(A)Tail And 5’-Cap Results In mRNA Instability
From the document ‘20201126_BNT162b2_EMAmeeting_final.pptx’, slide 19:
I will attempt to dejargonify this in a teaching moment.
Understanding Genetic Sequences
Before this can be deciphered: a little understanding of genetic sequences. Imagine a recipe that, if followed exactly, produces a cake.
This recipe might be in English, Latin, French, etc. For genetic sequences, it is written as ‘amino acids’, there are exceptions and technicalities but they are beyond the scope of what is needed here.
These ‘amino acids’ are:
Or, given how long they are, ‘A’, ‘G’, ‘C’ and ‘T’ for short, representing the first letter of their names. Genetic sequences represented in written works use these letters.
There’s a difference when it comes to the Pfizer mRNA — they replace ‘Thymine’ (T) with ‘Uridine’, represented by the Greek symbol Psi (Ψ). You can see evidence here [note: is a downloadable .doc from an archived copy of the WHO].
Takeaway: Genetic sequences are the recipe that tell the body to do stuff and we use letters and symbols to represent this in writing.
This may make some biologists mad, but simplicity will be favoured here. Essentially, genetic sequences can be coded either as ‘RNA’, which is a single strand of a genetic sequence, or ‘DNA’, which is a double strand (DNA is basically two RNA strands).
You can imagine them as strings. And the intertwined DNA as rope (rope is usually made from smaller strings). Strings can have different lengths, so you can take a small length of string (RNA) from a large length of string (also RNA), or you can take a piece of string (RNA) from a piece of rope (DNA).
However, instead of cutting out chunks of rope that would leave it threadbare like swiss cheese, what your body is doing is taking copies or clones of that string from that rope. This is called ‘replication’.
Transcription is the process of taking a piece of string (RNA) from a piece of rope (DNA) via copying (replication).
With string, you can cut different lengths. Lets say a string-cutter asked you to cut 5 inches of string, but you made a mistake due to a shaky hand, missed, and cut only 3 inches of string.
A shorter-than-intended length is known as ‘truncation’. So a ‘transcription truncation’ means when the RNA is transcripted from the DNA (when the string is cut from the rope), it was cut too short (truncated).
The way to imagine this in terms of genetic sequences is if a sentence cuts off mid-way through:
Julia emerged with the knife, poised, she was about t-
About to what? We don’t know. Part of the sentence is truncated.
Truncated RNA are missing parts of the letters of the required sequence, which means the instructions are incomplete.
Understanding 5'-Cap Truncation
A “5’-cap”, also known as a ‘5-prime-cap’, is, for simplicity again, a part of the RNA genetic sequence used for stability of mRNA sequences.
RNA can technically be ‘anything’, any length, any purpose, but if we want to turn RNA into mRNA specifically (a bit like giving a person a coat to go out into the snow), we have to give it a ‘5-prime-cap’.
mRNA is still RNA, but the ‘m’ classifies the purpose: messenger. It’s used to deliver RNA message payloads to cells. Basically a delivery service, that takes a piece of string and delivers it to a ropemaker and stringcutter in a cell. In order to travel from cell-to-cell it has to be stable against the elements, like a postman wearing a coat in the snow.
5-prime-cap Is Structural Support
This is where things get a bit complex: RNA might be written instructions, but they’re written in the physical.
It is a bit like using a set of different bricks in your house wall to signal a message to the outside world; each brick brings a different structural strength and weakness. Mud brick is weak, concrete brick is strong. Concrete brick on top of mud brick is weak and unstable.
Some brick formations — like ‘5-prime-cap’ — bring structural support to the house. A bit like an arch or a pillar.
If that pillar is missing (the ‘5-prime-cap’ is missing or lacking), two things occur: the structure of the building is no longer sound, and the instructions on how to build the house are mangled. This means when engineers copy the physical house design, they also copy the structural defects and the missing structural arch.
Defects beget defects.
The Poly(A) Tail Is Also Structural Support
At the end of the Pfizer mRNA is an extended length of ‘A’, which you now know to be the amino acid Adenine. These extended As determine the stability of the mRNA. The longer, the more stable, as a rough rule of thumb. You can imagine it a bit like how many sandbags you pile together at the base of a loose-brick wall to stop it falling over.
From the document ‘20201126_BNT162b2_EMAmeeting_final.pptx’, slide 5, we see that they mention that the poly(A) tail is lacking from the truncated mRNA:
Fragmented species observed by CGE are expected to be comprised of truncated transcripts that include the 5’ region of BNT162b2 but lack the 3’ region and poly(A) tail
This means they lack the structural support of the poly(A) tail, and are thus prone to ‘degradation’ (read: instability).
Bad Recipes Lead To Bad Results
Ever tried to follow a video tutorial where the tutor has missed a number of crucial steps, or failed to cover edge-cases, or is out-of-date, referencing missing material?
mRNA instability is much like that. Missing pieces lead to incoherent results.
With a tutorial, you might notice something is wrong, and stop following. But the human body is more like a machine, it doesn’t know something is wrong, so it keeps going.
It diligently executes code to the letter, no matter how absurd the results. It is how viruses are able to spread.
Anyone who tried to program a robot, giving it incorrect instructions will testify how horribly wrong a diligently following robot can go. Same occurs with the human body.
Putting It All Together (To Pull It Apart)
So what the slide is telling us that if, during the process of mRNA copying, the mRNA gets truncated, if any of the parts that provide the structural support to the mRNA gets cut off and mangled, the mRNA becomes unstable.
As a result, the mRNA starts to degrade in integrity, where errors are introduced to the script (genetic sequence). These mutant mRNA enter cells, and more defective copies are made.
What’s The Danger?
What could these defective copies do? Well, potentially, like a crazy man on drugs with a knife, possibly anything. The fact we don’t know is evidence that it isn’t safe because there haven’t been sufficient tests to know what these worst case scenarios are.
One known possibility is the defective mRNA will encode an incorrectly shaped spike protein, which means you become immune to some unknown shape design. This spike could hypothetically look like anything — including the shape of friendly proteins used normally by your own cells.
This would no doubt lead to auto-immune conditions, and serious immune reactions to exposures of similar spikes, like we’re already seeing.
The EMA leak documents say plenty more on the subject, which will be covered in a future article.
In the meantime:
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